Well I have been using the final release of Visual Studio 2010 for about a week now on a Windows 7 64bit platform and no issues so far. Have upgraded a few projects from VS2008 and all worked fine. Really like the breakout window feature. For my development setup, I use two ethernet ports. Finding a USB to ethernet adapter was a little time consuming, but the Trendnet works fine with the 64 bit setup, unlike the Belkin which did not work with the 64 bit platform. Tested the .net Logix version 2 software and all worked ok via the ethernet adapter. Upcoming test will be a USB to Serial port adapter and talking to some RS232 secondary devices and will also be testing the .net ID Automation forms control. The other software is Adobe CS5, in particular, Photoshop and Dreamweaver. One of the best new features for Photoshop is the new selection tools. It works a lot better than CS4. In Dreamweaver CS5, it now supports 3rd party content management frameworks. I tested it with WordPress and it worked great and was able to do live previews right within Dreamweaver! The big question is do you upgrade to Visual Studio 2010 and Adobe Cs5, and it all depends on your goals and needs. If you want the latest and greatest development tools, then its a must have.